diff --git a/lib/web/cache/cache.js b/lib/web/cache/cache.js
index 45c6fec3467..1c1a5911242 100644
--- a/lib/web/cache/cache.js
+++ b/lib/web/cache/cache.js
@@ -37,6 +37,7 @@ class Cache {
       webidl.illegalConstructor()
     }
 
+    webidl.util.markAsUncloneable(this)
     this.#relevantRequestResponseList = arguments[1]
   }
 
diff --git a/lib/web/cache/cachestorage.js b/lib/web/cache/cachestorage.js
index cc773b94b49..55dba352e99 100644
--- a/lib/web/cache/cachestorage.js
+++ b/lib/web/cache/cachestorage.js
@@ -16,6 +16,8 @@ class CacheStorage {
     if (arguments[0] !== kConstruct) {
       webidl.illegalConstructor()
     }
+
+    webidl.util.markAsUncloneable(this)
   }
 
   async match (request, options = {}) {
diff --git a/lib/web/eventsource/eventsource.js b/lib/web/eventsource/eventsource.js
index 51634c1779f..5a488ffce27 100644
--- a/lib/web/eventsource/eventsource.js
+++ b/lib/web/eventsource/eventsource.js
@@ -105,6 +105,8 @@ class EventSource extends EventTarget {
     // 1. Let ev be a new EventSource object.
     super()
 
+    webidl.util.markAsUncloneable(this)
+
     const prefix = 'EventSource constructor'
     webidl.argumentLengthCheck(arguments, 1, prefix)
 
diff --git a/lib/web/fetch/formdata.js b/lib/web/fetch/formdata.js
index 94a84b03ab3..544e4125519 100644
--- a/lib/web/fetch/formdata.js
+++ b/lib/web/fetch/formdata.js
@@ -14,6 +14,8 @@ const File = globalThis.File ?? NativeFile
 // https://xhr.spec.whatwg.org/#formdata
 class FormData {
   constructor (form) {
+    webidl.util.markAsUncloneable(this)
+
     if (form !== undefined) {
       throw webidl.errors.conversionFailed({
         prefix: 'FormData constructor',
diff --git a/lib/web/fetch/headers.js b/lib/web/fetch/headers.js
index 816aceacce4..a68daf4a5d4 100644
--- a/lib/web/fetch/headers.js
+++ b/lib/web/fetch/headers.js
@@ -359,6 +359,8 @@ class Headers {
   #headersList
 
   constructor (init = undefined) {
+    webidl.util.markAsUncloneable(this)
+
     if (init === kConstruct) {
       return
     }
diff --git a/lib/web/fetch/request.js b/lib/web/fetch/request.js
index 542ea7fb28a..ee3ce488774 100644
--- a/lib/web/fetch/request.js
+++ b/lib/web/fetch/request.js
@@ -82,6 +82,7 @@ let patchMethodWarning = false
 class Request {
   // https://fetch.spec.whatwg.org/#dom-request
   constructor (input, init = {}) {
+    webidl.util.markAsUncloneable(this)
     if (input === kConstruct) {
       return
     }
diff --git a/lib/web/fetch/response.js b/lib/web/fetch/response.js
index 155dbadd1ad..3b6af35fbed 100644
--- a/lib/web/fetch/response.js
+++ b/lib/web/fetch/response.js
@@ -110,6 +110,7 @@ class Response {
 
   // https://fetch.spec.whatwg.org/#dom-response
   constructor (body = null, init = {}) {
+    webidl.util.markAsUncloneable(this)
     if (body === kConstruct) {
       return
     }
diff --git a/lib/web/fetch/webidl.js b/lib/web/fetch/webidl.js
index 13cafae6f1b..cd5cb14454c 100644
--- a/lib/web/fetch/webidl.js
+++ b/lib/web/fetch/webidl.js
@@ -1,6 +1,7 @@
 'use strict'
 
 const { types, inspect } = require('node:util')
+const { markAsUncloneable } = require('node:worker_threads')
 const { toUSVString } = require('../../core/util')
 
 /** @type {import('../../../types/webidl').Webidl} */
@@ -86,6 +87,7 @@ webidl.util.Type = function (V) {
   }
 }
 
+webidl.util.markAsUncloneable = markAsUncloneable || (() => {})
 // https://webidl.spec.whatwg.org/#abstract-opdef-converttoint
 webidl.util.ConvertToInt = function (V, bitLength, signedness, opts) {
   let upperBound
diff --git a/lib/web/websocket/events.js b/lib/web/websocket/events.js
index 760b7297359..f899c21d42b 100644
--- a/lib/web/websocket/events.js
+++ b/lib/web/websocket/events.js
@@ -14,6 +14,7 @@ class MessageEvent extends Event {
   constructor (type, eventInitDict = {}) {
     if (type === kConstruct) {
       super(arguments[1], arguments[2])
+      webidl.util.markAsUncloneable(this)
       return
     }
 
@@ -26,6 +27,7 @@ class MessageEvent extends Event {
     super(type, eventInitDict)
 
     this.#eventInit = eventInitDict
+    webidl.util.markAsUncloneable(this)
   }
 
   get data () {
@@ -112,6 +114,7 @@ class CloseEvent extends Event {
     super(type, eventInitDict)
 
     this.#eventInit = eventInitDict
+    webidl.util.markAsUncloneable(this)
   }
 
   get wasClean () {
@@ -142,6 +145,7 @@ class ErrorEvent extends Event {
     webidl.argumentLengthCheck(arguments, 1, prefix)
 
     super(type, eventInitDict)
+    webidl.util.markAsUncloneable(this)
 
     type = webidl.converters.DOMString(type, prefix, 'type')
     eventInitDict = webidl.converters.ErrorEventInit(eventInitDict ?? {})
diff --git a/lib/web/websocket/websocket.js b/lib/web/websocket/websocket.js
index 109d7be2e2f..e4053024756 100644
--- a/lib/web/websocket/websocket.js
+++ b/lib/web/websocket/websocket.js
@@ -51,6 +51,8 @@ class WebSocket extends EventTarget {
   constructor (url, protocols = []) {
     super()
 
+    webidl.util.markAsUncloneable(this)
+
     const prefix = 'WebSocket constructor'
     webidl.argumentLengthCheck(arguments, 1, prefix)
 
diff --git a/test/node-platform-objects.js b/test/node-platform-objects.js
new file mode 100644
index 00000000000..19e2b01a507
--- /dev/null
+++ b/test/node-platform-objects.js
@@ -0,0 +1,33 @@
+'use strict'
+
+const { tspl } = require('@matteo.collina/tspl')
+const { test } = require('node:test')
+const { markAsUncloneable } = require('node:worker_threads')
+const { Response, Request, FormData, Headers, ErrorEvent, MessageEvent, CloseEvent, EventSource, WebSocket } = require('..')
+const { CacheStorage } = require('../lib/web/cache/cachestorage')
+const { Cache } = require('../lib/web/cache/cache')
+const { kConstruct } = require('../lib/core/symbols')
+
+test('unserializable web instances should be uncloneable if node exposes the api', (t) => {
+  if (markAsUncloneable !== undefined) {
+    t = tspl(t, { plan: 11 })
+    const uncloneables = [
+      { Uncloneable: Response, brand: 'Response' },
+      { Uncloneable: Request, value: 'http://localhost', brand: 'Request' },
+      { Uncloneable: FormData, brand: 'FormData' },
+      { Uncloneable: MessageEvent, value: 'dummy event', brand: 'MessageEvent' },
+      { Uncloneable: CloseEvent, value: 'dummy event', brand: 'CloseEvent' },
+      { Uncloneable: ErrorEvent, value: 'dummy event', brand: 'ErrorEvent' },
+      { Uncloneable: EventSource, value: 'http://localhost', brand: 'EventSource' },
+      { Uncloneable: Headers, brand: 'Headers' },
+      { Uncloneable: WebSocket, value: 'http://localhost', brand: 'WebSocket' },
+      { Uncloneable: Cache, value: kConstruct, brand: 'Cache' },
+      { Uncloneable: CacheStorage, value: kConstruct, brand: 'CacheStorage' }
+    ]
+    uncloneables.forEach((platformEntity) => {
+      t.throws(() => structuredClone(new platformEntity.Uncloneable(platformEntity.value)),
+        DOMException,
+        `Cloning ${platformEntity.brand} should throw DOMException`)
+    })
+  }
+})
diff --git a/types/webidl.d.ts b/types/webidl.d.ts
index 8a23a85bf01..fd83b68af90 100644
--- a/types/webidl.d.ts
+++ b/types/webidl.d.ts
@@ -67,6 +67,12 @@ interface WebidlUtil {
    * Stringifies {@param V}
    */
   Stringify (V: any): string
+
+  /**
+   * Mark a value as uncloneable for Node.js.
+   * This is only effective in some newer Node.js versions.
+   */
+  markAsUncloneable (V: any): void
 }
 
 interface WebidlConverters {