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title: DNA_replication_model
message: >-
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type: software
authors:
  - given-names: Francisco
    family-names: Berkemeier
    email: fp409@cam.ac.uk
    affiliation: University of Cambridge
    orcid: 'https://orcid.org/0000-0001-9850-3666'
repository-code: 'https://github.com/fberkemeier/DNA_replication_model'
url: 'https://github.com/fberkemeier/DNA_replication_model'
abstract: >-
  We provide a comprehensive toolkit for analyzing DNA
  replication timing, origin firing rates, and genomic
  stability across different cell lines and chromosome
  regions. The toolkit includes functions to load and
  process data for various genomic regions, including
  whole-genome, telomeres, centromeres, and specific genomic
  sites. By fitting origin firing rates to replication
  timing data, the toolkit enables efficient prediction and
  comparison of experimental and predicted timing data. The
  resulting error distribution between predicted and
  experimental timings is instrumental in identifying
  regions of interest. Leveraging datasets that encompass
  different chromosomes and genomic features, the project
  facilitates detailed visualization and analysis of
  replication dynamics and genomic stability.
keywords:
  - DNA
  - replication
  - genetics
license: MIT