diff --git a/src/core/base.js b/src/core/base.js
index e81c3fc07..4a42b3ba9 100644
--- a/src/core/base.js
+++ b/src/core/base.js
@@ -13,9 +13,10 @@
  */
 import "regenerator-runtime/runtime"; // needed for ``await`` support
 import $ from "jquery";
-import Registry from "./registry";
+import Registry, { PATTERN_INSTANCE_REGISTRY } from "./registry";
 import logging from "./logging";
 import mockupParser from "./mockup-parser";
+import utils from "./utils";
 
 const log = logging.getLogger("Patternslib Base");
 
@@ -50,10 +51,15 @@ const Base = async function ($el, options, trigger) {
     this.options = $.extend(true, {}, this.defaults || {}, options || {});
     await this.init($el, options, trigger);
 
+    this.id = utils.unique_id(); // Generate a unique id
+
     // Store pattern instance on element
     this.$el.data(`pattern-${this.name}`, this);
     this.el[`pattern-${this.name}`] = this;
 
+    // Add Pattern instance to PATTERN_INSTANCE_REGISTRY
+    PATTERN_INSTANCE_REGISTRY.push(this);
+
     this.emit("init");
 };
 
diff --git a/src/core/events.js b/src/core/events.js
index 09103de2d..0512986a0 100644
--- a/src/core/events.js
+++ b/src/core/events.js
@@ -14,9 +14,19 @@ const event_listener_map = {};
  * @param {string} id - A unique id under which the event is registered.
  * @param {function} cb - The event handler / callback function.
  * @param {Object} opts - Options for the addEventListener API.
- *
+ * @param {Function} remove_condition - If this function evaluates to true,
+ *      the event listener will be deregistered and not called.
+ *      Defaults to always return ``false``, so no check is actually done.
+ *      Can be used to unregister event handlers automatically.
  */
-const add_event_listener = (el, event_type, id, cb, opts = {}) => {
+const add_event_listener = (
+    el,
+    event_type,
+    id,
+    cb,
+    opts = {},
+    remove_condition = () => false
+) => {
     if (!el?.addEventListener) {
         return; // nothing to do.
     }
@@ -26,7 +36,15 @@ const add_event_listener = (el, event_type, id, cb, opts = {}) => {
         event_listener_map[el] = {};
     }
     event_listener_map[el][id] = [event_type, cb, opts.capture ? opts : undefined]; // prettier-ignore
-    el.addEventListener(event_type, cb, opts);
+    const _cb = () => {
+        if (remove_condition()) {
+            remove_event_listener(el, id);
+        } else {
+            cb();
+        }
+    };
+
+    el.addEventListener(event_type, _cb, opts);
 };
 
 /**
diff --git a/src/core/registry.js b/src/core/registry.js
index d4a7c3819..cb9f0d2a4 100644
--- a/src/core/registry.js
+++ b/src/core/registry.js
@@ -54,8 +54,23 @@ if (typeof window.__patternslib_registry_initialized === "undefined") {
     window.__patternslib_registry_initialized = false;
 }
 
+/**
+ * Global pattern instance registry.
+ *
+ * If your Pattern uses the base pattern base class, any concrete instance of
+ * the pattern will be stored in this registry.
+ * When the element on which the pattern is defined is removed, we call the
+ * ``destroy`` method on the pattern instance and remove the pattern instance
+ * from this registry.
+ */
+if (typeof window.__patternslib_instance_registry === "undefined") {
+    window.__patternslib_instance_registry = [];
+}
+export const PATTERN_INSTANCE_REGISTRY = window.__patternslib_instance_registry;
+
 const registry = {
     patterns: PATTERN_REGISTRY, // reference to global patterns registry
+    patterns_instances: PATTERN_INSTANCE_REGISTRY, // reference to global pattern instance registry
     // as long as the registry is not initialized, pattern
     // registration just registers a pattern. Once init is called,
     // the DOM is scanned. After that registering a new pattern
@@ -69,6 +84,19 @@ const registry = {
             window.__patternslib_registry_initialized = true;
             log.debug("Loaded: " + Object.keys(registry.patterns).sort().join(", "));
             registry.scan(document.body);
+
+            // Call the Pattern instance's destroy method when a Pattern element
+            // is removed.
+            const remove_observer = new MutationObserver((mutations, observer) => {
+                registry.pattern_instances.forEach((instance, idx) => {
+                    if (!document.body.contains(instance.el)) {
+                        instance?.destroy();
+                        delete registry.pattern_instances[idx];
+                    }
+                });
+            });
+            remove_observer.observe(document.body, { childList: true });
+
             log.debug("Finished initial scan.");
         });
     },
@@ -79,6 +107,9 @@ const registry = {
         for (const name in registry.patterns) {
             delete registry.patterns[name];
         }
+        registry.pattern_instances.forEach((instance, idx) => {
+            delete registry.pattern_instances[idx];
+        });
     },
 
     transformPattern(name, content) {
diff --git a/src/core/utils.js b/src/core/utils.js
index dabb624b7..7104b3031 100644
--- a/src/core/utils.js
+++ b/src/core/utils.js
@@ -642,6 +642,15 @@ const is_iso_date_time = (value, optional_time = false) => {
     return re_date_time.test(value);
 };
 
+/**
+ * Generate a unique id.
+ *
+ * @return {String} - A unique string.
+ */
+const unique_id = () => {
+    return Math.floor((1 + Math.random()) * 0x1000000000000).toString(16);
+};
+
 var utils = {
     // pattern pimping - own module?
     jqueryPlugin: jqueryPlugin,
@@ -673,6 +682,7 @@ var utils = {
     escape_html: escape_html,
     unescape_html: unescape_html,
     is_iso_date_time: is_iso_date_time,
+    unique_id: unique_id,
     getCSSValue: dom.get_css_value, // BBB: moved to dom. TODO: Remove in upcoming version.
 };